 |
|
 |
|
|
Thematic project title ： |
Marine Natural Products |
|
|
|
|
Researchers ： |
Ping-Jyun Sung、Mei-Chin Lu、Jui-Hsin Su、Jimmy Kuo
|
|
|
|
|
Content ： |
1. Study on the bioactive natural products from marine invertebrates and cultured octocorals.
2. Study on the bioactive natural products from marine microorganisms
3. Study on the bioactive natural products from octocorals and sponges and investigation on the synthesis and bioactivities of related analogues.
4. Anticancer research of marine natural products. |
|
|
|
|
Description ： |
Marine natural product chemistry has been continuously developing during the past 6 decades, and to date, marine natural product chemists have isolated more than 20,000 new compounds from marine organisms, including bacteria, fungi, microalgae, seaweeds, sponges and soft corals etc... Many of these compounds are structurally unique and have been shown to exhibit significant biological activity, and several compounds are expected to be important drug leads or potential drugs. The main purpose of this project is the discovery of medicinal marine natural products from Formosa marine invertebrates and marine microorganisms. |
|
|
|
|
Result ： |
2011年
1. Chen, B.-W.; Chao, C.-H.; Su, J.-H.; Tsai, C.-W.; Wang, W.-H.; Wen, Z.-H.; Hsieh, C.-H.; Sung, P.-J.; Wu, Y.-C.; Sheu, J.-H.* “Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex” Org. Biomol. Chem. 2011, 9, 534-544. (SCI)
2. Chung, H.-M.; Hwang, T.-L.; Chen, Y.-H.; Su, J-H.; Lu, M.-C.; Chen, J.-J.; Li, J.-J.; Fang, L.-S.; Wang, W.-H.*; Sung, P.-J.* “Rumphellclovane B, a Novel Clovane Analogue from the Gorgonian Coral Rumphella antipathies” Bull. Chem. Soc. Jpn., 2011, 84, 119-121. (SCI)
3. Lu, Y., Li, P.-J.; Hung, W.-Y.; Su, J.-H.; Wen, Z.-H.; Hsu, C.-H.; Dai, C.-F.; Chiang, M. Y.; Sheu, J.-H.* “Nardosinane Sesquiterpenoids from the Formosan Soft Coral Lemnalia flava” J. Nat. Prod. 2011, 73, 169–174. (SCI)
4. Liao, Z.-J.; Su, H.-J.; Shyue, Y.-C.; Wen, Z.-H.; Sheu, J.-H ; * Su, J.-H.* “Two New Cembranoids from the Soft Coral Lobophytum crassum” Bull. Chem. Soc. Jpn,. (accepted) (SCI)
5. Lu, Y.; Su, H.-J.; Chen, Y.-H. Wen, Z.-H.; Sheu, J.-H. Su, J.-H.* “Anti-inflammatory Cembranoids from the Formosan Soft Coral Sinularia discrepans“ Archives of Pharmacal Research, 2011. (accepted) (SCI)
6. Wu, S.-L.; Su, J.-H.; Lu, Y.; Chen, B.-W.; Huang, C.-Y.; Wen, Z.-H.; Kuo, Y.-H. Sheu, J.-H.* “Simplexins J–O, Eunicellin-Based Diterpenoids from a Dongsha Atoll Soft Coral Klyxum simplex” Bull. Chem. Soc. Jpn,. 2011.(accepted) (SCI)
7. Su, J.-H.; Lu, Y.; Hung, W.-Y.; Huang, C.-Y.; Chiang, M. Y.; Sung, P.-J.; Sheu, J.-H.* “Sesquiterpenoids from the Formosan Soft Coral Lemnalia flava” Chem. Pharm. Bull. 2011. (accepted) (SCI)
8. Sheu, J.-H.* Chen, B.-W.; Chang, S.-M. Huang, C.-Y.; Su, J.-H.; Wen, Z.-H.; Wu, Y.-C. “ Hirsutosterols A–G, Polyoxygenated Steroids from a Formosan Soft Coral Cladiella hirsuta“ Org. Biomol. Chem. (accepted) (SCI)
9. Chen, Y.-H.; Tai, C.-Y.; Kuo, Y.-H.; Kao, C.-Y.; Li, J.-J.; Hwang, T.-L.; Fang, L.-S.; Wang, W.-H.; Sheu, J.-H.*; Sung, P.-J.* Cladieunicellins A-E, New Eunicellins from an Indonesian Soft Coral Cladiella sp. Chem. Pharm. Bull. 2011, 59, 353–358. (SCI)
10. Tai, C.-Y.; Chen, Y.-H.; Hwang, T.-L.; Fang, L.-S.; Wang, W.-H.; Liu, M.-C.; Wu, Y.-C.; Sung, P.-J.* Cladielloides C and D: Novel Eunicellin-based Diterpenoids from an Indonesian Octocoral Cladiella sp. Bull. Chem. Soc. Jpn. 2011, 84, (accepted) (SCI)
11. Sung, P.-J.*; Su, J.-H.; Wang, W.-H.; Sheu, J.-H.; Fang, L.-S.; Wu, Y.-C.; Chen, Y.-H.; Chung, H.-M.; Su, Y.-D.; Chang, Y.-C. Survey of Briarane-Type Diterpenoids–Part IV. Heterocycles 2011, 83, in press. (SCI) |
|
|
|
|
Relaction Projects： |
|
|
|
|
|
|
|
|
|
 |
|
|
 |
|
 |
|